标签归档：adenylosuccinic

Adenylosuccinic acid (Synonyms: Adenylosuccinate; Aspartyl adenylate)

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Adenylosuccinic acid  (Synonyms: Adenylosuccinate; Aspartyl adenylate)

Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) 是一种嘌呤核糖核苷单磷酸，在核苷酸循环代谢 (nucleotide cycle metabolite) 中起作用。Adenylosuccinic acid 可以通过腺苷琥珀酸裂解酶转化成富马酸。Adenylosuccinic acid 有潜力用于杜氏肌营养不良症 (DMD) 的研究。

Adenylosuccinic acid (Synonyms: Adenylosuccinate; Aspartyl adenylate)

Adenylosuccinic acid Chemical Structure

CAS No. : 19046-78-7

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Adenylosuccinic acid 的其他形式现货产品:

Adenylosuccinic acid tetraammonium

Adenylosuccinic acid 相关产品

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生物活性

Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1].

IC50 & Target

Human Endogenous Metabolite

 

体内研究
(In Vivo)

Adenylosuccinic acid (oral administration; 3-3000 µg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+ content of mdx tibialis anterior[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/10ScSn (normal wild-type strain; Con) and C57Bl/10mdx (mdx) mice[1]
Dosage: 3 µg/mL, 30 µg/mL, 300 µg/mL, 3000 µg/mL
Administration: 3 µg/mL for 3 days and 30 µg/mL for the next 4 days, and 300 µg/mL for one week, and then 3000 µg/mL for 6 weeks
Result: Ameliorated the symptoms of murine duchenne muscular dystrophy.

分子量

463.29

Formula

C14H18N5O11P
CAS 号

19046-78-7
初始来源
  • 内源性代谢物
  • 人肠道微生物代谢物
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Timpani CA, et al. Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy.Sci Rep. 2020 Jan 24;10(1):1125.  [Content Brief]

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