Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

Doxorubicinol 抑制分离的乳头肌的舒张功能（即增加静息压）^[1]。
Doxorubicinol 在显著降低舒张功能的浓度下，阿霉素几乎完全消除钙泵活性^[1]。
Doxorubicinol 抑制 Ca2+ 刺激的骨骼肌肌浆网的 ATP 酶活性，并消除犬和兔心脏制备物中肌膜的 Na+/K+-ATP 酶活性^[1]。
Doxorubicinol 抑制 PANC-1 细胞的增殖，IC₅₀ 值为 35.4 μM，PD PaCa 细胞的 IC₅₀ 值为 44.5 μM，WD PaCa 细胞的 IC₅₀ 值为 49.5 μM^[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

545.54

C₂₇H₃₁NO₁₁

54193-28-1

• Quinones
• Anthraquinones

• 内源性代谢物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85(10):3585-9.  [Content Brief]