标签归档：ammonium

Cyclic ADP-​ribose ammonium (Synonyms: cADPR ammonium)

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Cyclic ADP-​ribose ammonium  (Synonyms: cADPR ammonium) 纯度: ≥99.0%

Cyclic ADP-ribose ammonium (cADPR ammonium) 是一种有效的钙动员 (calcium mobilization) 第二信使，是通过 ADP-核糖基环化酶从 NAD+ 合成的。Cyclic ADP-ribose ammonium 主要通过 Ryanodine 受体介导的内质网释放以及通过 TRPM2 通道开放引起的细胞外流入来增加胞质钙。

Cyclic ADP-​ribose ammonium (Synonyms: cADPR ammonium)

Cyclic ADP-​ribose ammonium Chemical Structure

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500 μg ￥5500 In-stock

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Cyclic ADP-​ribose ammonium 相关产品

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生物活性

Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3].

IC50 & Target

Calcium mobilization[1]
TRPM2 channels[3]
Endogenous metabolite[1]
体外研究
(In Vitro)

cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].
cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].
cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic ADP-​ribose ammonium 相关抗体:
体内研究
(In Vivo)

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Formula

C15H21N5O13P2.xNH3
性状

固体

颜色

White to off-white

结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (540 KB) SDS (251 KB)

COA (272 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Galione A, et, al. Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science. 1991 Sep 6;253(5024):1143-6.  [Content Brief]

    [2]. Lee HC, et, al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. J Biol Chem. 1989 Jan 25;264(3):1608-15.  [Content Brief]

    [3]. Ribeiro JM, et, al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn 2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8(1):1036.  [Content Brief]

    [4]. Verderio C, et, al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. J Neurochem. 2001 Aug;78(3):646-57.  [Content Brief]

    [5]. Zhong J, et, al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Front Neurosci. 2016 Jul 22;10:304.  [Content Brief]

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