Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division^[1].

IC50: 0.01 nM (HeLa S3 cells)^[1].
EC50: 1.3 μM (F-actin)^[1]

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC₅₀ value of 0.01 nM^[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC₅₀ value of 1.3 μM in vitro actin-depolymerizing assay^[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells^[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

1076.44

C₅₉H₁₀₁N₃O₁₄

151923-84-1

• Alkaloids

• Others

• 动物

Aplysia kurodai

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Masaki Kita, et al. Fluorescent aplyronine a: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells. Chembiochem. 2012 Aug 13;13(12):1754-8, 1702.  [Content Brief]