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Argininosuccinic acid

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Argininosuccinic acid 

Argininosuccinic acid 参与尿素循环的第四步，被精氨酸琥珀酸裂解酶 (ASL) 裂解为精氨酸和富马酸。Argininosuccinic acid 降低还原型谷胱甘肽 (GSH) 浓度，增加大脑皮层和纹状体的活性氧生成。Argininosuccinic acid 可引起脂质过氧化和蛋白质氧化，还在发育中大鼠脑中诱导氧化应激。

Argininosuccinic acid

Argininosuccinic acid Chemical Structure

CAS No. : 2387-71-5

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Argininosuccinic acid 的其他形式现货产品:

Argininosuccinic acid disodium

Argininosuccinic acid 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain[1][2].

体外研究
(In Vitro)

Argininosuccinic acid (250-1000 μM; 1 h) 显著增加丙二醛水平，减少巯基和羰基的形成 (蛋白质氧化) 在大脑皮层[1]。
Argininosuccinic acid (250-1000 μM; 1 h) 降低 30 日龄大鼠大脑皮层还原性谷胱甘肽 (GSH) 浓度[1]。
Argininosuccinic acid (500 μM; 1 h) 增加了30 日龄大鼠大脑皮层的二氯荧光黄含量[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Argininosuccinic acid 相关抗体:
体内研究
(In Vivo)

Argininosuccinic acid (2 μM, 2 μL; 头部注射; 单剂量) 能显著诱导 30 日龄大鼠的氧化应激[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 30-day-old rats with two small holes drilled in the skull[1]
Dosage: 2 μL of a 1.0 M concentration (2 μmol in 2 μL)
Administration: Injection; euthanized 2 h after treatment
Result: Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation).
Significantly decreased GSH concentrations.

分子量

290.27

Formula

C10H18N4O6
CAS 号

2387-71-5
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244.  [Content Brief]

    [2]. Nagamani SCS, et al. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023.  [Content Brief]

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