标签归档：asimilobine

Asimilobine (Synonyms: 巴婆碱)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Asimilobine  (Synonyms: 巴婆碱)

Asimilobine 是从木兰的植物中分离出的一种阿朴啡型异喹啉生物碱。Asimilobine 是多巴胺 (dopamine) 生物合成的抑制剂，也是血清素能受体 (serotonergic receptor) 拮抗剂。Asimilobine 具有抗疟 (antimalarial) 和抗癌活性。

Asimilobine (Synonyms: 巴婆碱)

Asimilobine Chemical Structure

CAS No. : 6871-21-2

规格 价格 是否有货 数量
1 mg ￥980 1 周
5 mg ￥2400 1 周
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Asimilobine 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].

IC50 & Target[1][2]

Plasmodium

 

Dopamine Receptor

 

serotonergic receptor

 

体外研究
(In Vitro)

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM[2].
Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h[2].
Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Asimilobine 相关抗体:
分子量

267.32

Formula

C17H17NO2
CAS 号

6871-21-2
中文名称

巴婆碱
结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
  • Phenols
  • Monophenols
初始来源
  • 植物
  • 睡莲科
  • 莲
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50(4):773-4.  [Content Brief]

    [2]. Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10(7-8):747-55.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务