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Bafilomycin C1 (Synonyms: 巴菲霉素C1) 纯度: ≥99.0%
Bafilomycin C1 是从链霉菌中分离得到的大环内酯类抗生素 (antibiotic)。Bafilomycin C1 是一种有效的、特异性的、可逆的 vacuolar-type H+-ATPases 抑制剂。Bafilomycin C1 抑制革兰氏阳性菌 (bacteria) 和真菌 (fungi) 的生长。Bafilomycin C1 可诱导细胞凋亡 (apoptosis),可用于肝细胞癌 (HCC) 的研究。
Bafilomycin C1 Chemical Structure
CAS No. : 88979-61-7
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥3500 | In-stock | |
5 mg | ¥9800 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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Bafilomycin C1 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Macrocyclic Compound Library
生物活性 |
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC)[2]. |
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IC50 & Target |
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体外研究 (In Vitro) |
Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner[2].Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells[2].Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
Western Blot Analysis[2]
Apoptosis Analysis[2]
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体内研究 (In Vivo) |
Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
720.89 |
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Formula |
C39H60O12 |
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CAS 号 |
88979-61-7 |
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性状 |
固体 |
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颜色 |
White to off-white |
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中文名称 |
巴菲霉素C1 |
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结构分类 |
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初始来源 |
Streptomyces sp |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 5 mg/mL (6.94 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) 配制储备液
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
In Vivo:
以下溶解方案源自文献,仅供参考,建议您先取少量样品进行尝试。
动物溶解方案计算器
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给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
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纯度 & 产品资料 |
纯度: ≥99.0%
Data Sheet (607 KB) SDS (420 KB)
COA (194 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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