标签归档：cadpr

Cyclic ADP-​ribose (Synonyms: 环状ADP核糖; cADPR)

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Cyclic ADP-​ribose  (Synonyms: 环状ADP核糖; cADPR)

Cyclic ADP-ribose (cADPR) 是一种有效的钙动员 (calcium mobilization) 第二信使，是通过 ADP-核糖基环化酶从 NAD+ 合成的。Cyclic ADP-ribose 主要通过 Ryanodine 受体介导的内质网释放以及通过 TRPM2 通道开放引起的细胞外流入来增加胞质钙。

Cyclic ADP-​ribose (Synonyms: 环状ADP核糖; cADPR)

Cyclic ADP-​ribose Chemical Structure

CAS No. : 119340-53-3

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Cyclic ADP-​ribose 的其他形式现货产品:

Cyclic ADP-​ribose ammonium

Cyclic ADP-​ribose 相关产品

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生物活性

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3].

IC50 & Target

Calcium mobilization[1]
TRPM2 channels[3]
Endogenous metabolite[1]
体外研究
(In Vitro)

cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].
cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].
cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic ADP-​ribose 相关抗体:
体内研究
(In Vivo)

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

541.30

Formula

C15H21N5O13P2
CAS 号

119340-53-3
性状

固体

颜色

White to off-white

中文名称

环状ADP核糖； 环二磷酸腺苷核酸糖
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Shipping with dry ice.
储存方式

-80°C
溶解性数据
In Vitro: 

H2O 中的溶解度 : 5 mg/mL (9.24 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8474 mL 9.2370 mL 18.4740 mL
5 mM 0.3695 mL 1.8474 mL 3.6948 mL
10 mM — — —

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months。-80°C 储存时，请在6个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

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  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

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动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

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纯度 & 产品资料

纯度: ≥96.0%

Data Sheet (613 KB) SDS (251 KB)

COA (270 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Galione A, et, al. Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science. 1991 Sep 6;253(5024):1143-6.  [Content Brief]

    [2]. Lee HC, et, al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. J Biol Chem. 1989 Jan 25;264(3):1608-15.  [Content Brief]

    [3]. Ribeiro JM, et al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8(1):1036.  [Content Brief]

    [4]. Verderio C, et, al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. J Neurochem. 2001 Aug;78(3):646-57.  [Content Brief]

    [5]. Zhong J, et, al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Front Neurosci. 2016 Jul 22;10:304.  [Content Brief]

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