Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA^[1][2].

Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis^[1].
Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA ^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

388.35

C₂₀H₁₇N₂NaO₅

25387-67-1

固体

Light yellow to light brown

喜树碱钠盐

• Alkaloids
• Quinoline Alkaloids

• Alkaloids
• Pyrrole Alkaloids

• 植物
• 蓝果树科
• 喜树

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

H₂O 中的溶解度 : 50 mg/mL (128.75 mM; 超声助溶)

DMSO 中的溶解度 : 25 mg/mL (64.37 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3009-14.  [Content Brief]

  [2]. M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48(3):690-8  [Content Brief]