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α-Chaconine (Synonyms: 阿尔法卡茄碱) 纯度: 99.04%
α-Chaconine 可在转录水平抑制 COX-2，IL-1β，IL-6 和 TNF-α 表达。α-Chaconine 作用于 RAW 264.7 巨噬细胞，在蛋白和 mRNA 水平上抑制 LPS 诱导的 iNOS 和 COX-2 表达及其启动子活性。α-Chaconine 具有抗炎作用。
α-Chaconine Chemical Structure
CAS No. : 20562-03-2
| 规格 | 价格 | 是否有货 | 数量 |
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| 1 mg | ￥3500 | In-stock | |
| 5 mg | 询价 | ||
| 10 mg | 询价 |
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α-Chaconine 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
| 生物活性 |
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects[1]. |
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| 体外研究 (In Vitro) |
α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
852.06 |
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| Formula |
C45H73NO14 |
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| CAS 号 |
20562-03-2 |
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| 性状 |
固体 |
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| 颜色 |
White to off-white |
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| 中文名称 |
阿尔法卡茄碱 |
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| 结构分类 |
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| 初始来源 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 纯度 & 产品资料 |
纯度: 99.04%
Data Sheet (531 KB) SDS (252 KB)
COA (271 KB) HNMR (123 KB) RP-HPLC (213 KB) 产品使用指南 (1538 KB) |
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| 参考文献 |
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