标签归档：cleistanthin

Cleistanthin B (Synonyms: Diphyllin O-glucoside)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Cleistanthin B  (Synonyms: Diphyllin O-glucoside) 纯度: ≥99.0%

Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用，EC50 值为 6.51 µM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。

Cleistanthin B (Synonyms: Diphyllin O-glucoside)

Cleistanthin B Chemical Structure

CAS No. : 30021-77-3

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1 mg ￥6400 In-stock
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Cleistanthin B 相关产品

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生物活性

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2)[1]
体外研究
(In Vitro)

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1].
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cleistanthin B 相关抗体:
体内研究
(In Vivo)

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

542.49

Formula

C27H26O12
CAS 号

30021-77-3
性状

固体

颜色

Light yellow to yellow

结构分类
  • Phenylpropanoids
  • Lignans
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (536 KB) SDS (251 KB)

COA (274 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.  [Content Brief]

    [2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.  [Content Brief]

    [3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.  [Content Brief]

    [4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.  [Content Brief]

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