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Acetoacetyl-CoA

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Acetoacetyl-CoA 

Acetoacetyl CoA 是甲羟戊酸途径中 HMG-CoA 的前体。Acetoacetyl-CoA thiolase 催化两个 acetyl-CoA 分子形成 Acetoacetyl CoA。Acetoacetyl CoA 对胆固醇生物合成至关重要。Acetoacetyl CoA 也是脂肪酸的生物分解和合成的中间体。

Acetoacetyl-CoA

Acetoacetyl-CoA Chemical Structure

CAS No. : 1420-36-6

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生物活性

Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

The purified recombinant Msed_0389 and Msed_1423 catalyze the NAD-dependent oxidation of (S)-3-hydroxybutyryl-CoA to Acetoacetyl-CoA and are highly specific for their substrate (Km of 2.6 μM and 5 μM, respectively)[2].
The homologous bifunctional protein is the only enzyme capable to covert crotonyl-CoA into Acetoacetyl-CoA in autotrophic Desulfurococcales (Ignicoccus hospitalis) and Thermoproteales (Pyrobaculum neutrophilus) that use the dicarboxylate/4-hydroxybutyrate cycle for CO2 fixation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Acetoacetyl-CoA 相关抗体:
分子量

851.61

Formula

C25H40N7O18P3S
CAS 号

1420-36-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Miziorko HM. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys. 2011 Jan 15;505(2):131-43.  [Content Brief]

    [2]. Liu L, et al. Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula. Front Microbiol. 2020 Mar 11;11:354.  [Content Brief]

    [3]. Feodor Lynen, et al. Enzymes of fatty acid metabolism. Biochimica et Biophysica Acta. Volume 12, Issues 1-2, October 1953, Pages 299-314.

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