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Curdione (Synonyms: 莪术二酮; (+)-Curdione) 纯度: 99.92%
莪术二酮 (Curdione)是从莪术中分离到的倍半萜类物质,生物活性高,具有抑制血小板聚集、抵抗血栓形成的功效。
Curdione Chemical Structure
CAS No. : 13657-68-6
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥220 | In-stock | |
5 mg | ¥550 | In-stock | |
10 mg | ¥860 | In-stock | |
50 mg | ¥2400 | In-stock | |
100 mg | ¥3600 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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生物活性 |
Curdione, one of the major sesquiterpene compounds from Curcuma zedoaria, has been shown to exhibit multiple bioactive properties. IC50 value: 60–80 μM Target: In vitro: The study of the influence of curdione on the hemorheological changes in blood stasis model rats and thrombolysis in vitro showed that curdione only possessed thrombolytic effect in dose of 0.235 g·L-1 and 2.35 g·L-1, but has not the notable activity of thrombolysis [1]. The effects of curdione on human platelet aggregation induced by thrombin (0.3 U/ml) were tested in vitro. Curdione preferentially inhibited PAF- and thrombin- induced platelet aggregation in a concentration-dependent manner (IC50: 60–80 μM), whereas much higher concentrations of curdione were required to inhibit platelet aggregation induced by ADP and AA. Curdione also inhibited P-selectin expression in PAF-activated platelets. Moreover, curdione caused an increase in cAMP levels and attenuated intracellular Ca2+ mobilization in PAF-activated platelets. In vivo: Curdione showed significant antithrombotic activity [2]. |
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分子量 |
236.35 |
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Formula |
C15H24O2 |
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CAS 号 |
13657-68-6 |
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性状 |
固体 |
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颜色 |
White to off-white |
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中文名称 |
莪术二酮;姜黄二酮;莪二酮 |
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结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 100 mg/mL (423.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
In Vivo:
请根据您的 实验动物和给药方式 选择适当的溶解方案。 以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
动物溶解方案计算器
请输入动物实验的基本信息:
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
请输入您的动物体内配方组成:
%
DMSO + %
%
Tween-80 + %
Saline 如果您的动物是免疫缺陷鼠或者体弱鼠,建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。 方案所需 助溶剂 包括:DMSO, ,均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。 ,Tween 80,均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL DMSO(母液浓度为 mg/mL)。
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E-mail:sales@jinpanbio.com 技术支持电话:021-50837765 技术支持邮箱:sales@jinpanbio.com 动物实验体内工作液的配制方法 : 取 μL DMSO 储备液,加入 μL 。 μL ,混合均匀至澄清,再加 μL Tween 80,混合均匀至澄清,再加 μL 生理盐水。
连续给药周期超过半月以上,请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态,从左到右依次添加助溶剂。您可采用超声加热 (超声清洗仪,建议频次 20-40 kHz),涡旋吹打等方式辅助溶解。
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纯度 & 产品资料 |
纯度: 99.92%
Data Sheet (623 KB) SDS (393 KB)
COA (196 KB) RP-HPLC (244 KB) LCMS (88 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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