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CV1808 (Synonyms: 2-Phenylaminoadenosine)

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CV1808  (Synonyms: 2-Phenylaminoadenosine) 纯度: ≥98.0%

CV1808 (2-Phenylaminoadenosine) 是一种非选择性 A2 腺苷受体 (A2 AR) 激动剂，对 A2A 和 A3 腺苷受体亚型的 Ki 分别为 76 和 1450 nM。

CV1808 (Synonyms: 2-Phenylaminoadenosine)

CV1808 Chemical Structure

CAS No. : 53296-10-9

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生物活性

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].

体外研究
(In Vitro)

CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM[1].
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

CV1808 相关抗体:
体内研究
(In Vivo)

Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rat, weighing 370-410 g[3]
Dosage: 0.002, 0.02, 0.2, and 2 μM
Administration: Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result: Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.

分子量

358.35

Formula

C16H18N6O4
CAS 号

53296-10-9
性状

固体

颜色

Off-white to light yellow

中文名称

2-苯基氨基腺苷
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (531 KB) SDS (251 KB)

COA (266 KB) 元素分析报告 (213 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. K H Yip, et al. Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors. Br J Pharmacol. 2011 Sep;164(2b):807-19.  [Content Brief]

    [2]. I van der Ploeg,et al.Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn Schmiedebergs Arch Pharmacol.1996 Feb;353(3):250-60.  [Content Brief]

    [3]. Ming-Guo Feng, et al. Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Renal Physiol. 2010 Aug;299(2):F310-5.  [Content Brief]

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