标签归档：ditartrate

Vinorelbine-d3 ditartrate(Synonyms: KW-2307-d3 ditartrate; Nor-5′-anhydrovinblastine-d3 ditartrate)

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Vinorelbine-d3 ditartrate (Synonyms: KW-2307-d3 ditartrate; Nor-5′-anhydrovinblastine-d3 ditartrate)

Vinorelbine-d3 (KW-2307-d3) ditartrate 是 Vinorelbine ditartrate 的氘代物。Vinorelbine ditartrate 是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC50值为 1.25 nM。

Vinorelbine-d3 ditartrate(Synonyms: KW-2307-d3 ditartrate; Nor-5

Vinorelbine-d3 ditartrate Chemical Structure

CAS No. : 35674-14-7

规格 是否有货
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生物活性

Vinorelbine-d3 (KW-2307-d3) ditartrate is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1082.12

Formula

C53H63D3N4O20
CAS 号

35674-14-7
中文名称

酒石酸长春瑞滨 d3 (双酒石酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32.

    [3]. Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73.

    [4]. Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9.

    [5]. Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8.

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