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Thymidine 5′-diphosphate (Synonyms: dTDP)

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Thymidine 5′-diphosphate  (Synonyms: dTDP)

Thymidine 5′-diphosphate (dTDP) 是生物体内合成嘧啶的关键产物。Thymidine 5′-diphosphate 由胸苷酸激酶 (TMPK) 催化5′-单磷酸胸苷 (dTMP) 磷酸化而产生，该过程需要 ATP 和 Mg2+。Thymidine 5′-diphosphate 再进一步被 TMPK 催化为胸苷 5′-三磷酸 (dTTP)。检测 Thymidine 5′-diphosphate 水平可以检测 TMPK 活性。

Thymidine 5′-diphosphate (Synonyms: dTDP)

Thymidine 5′-diphosphate Chemical Structure

CAS No. : 491-97-4

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生物活性

Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate[1][2].

IC50 & Target

Human Endogenous Metabolite

 

分子量

402.19

Formula

C10H16N2O11P2
CAS 号

491-97-4
结构分类
  • Others
初始来源
  • 内源性代谢物
  • 人肠道微生物代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Cui Q, et al. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305.  [Content Brief]

    [2]. Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26(11):2225-30.  [Content Brief]

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