Thiabendazole-d4(Synonyms: 2-(4-Thiazolyl)benzimidazole-d4)

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Thiabendazole-d4 (Synonyms: 2-(4-Thiazolyl)benzimidazole-d4)

Thiabendazole-d4 是 EIDD-1931 氘代物。EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) 是一种核苷类物质,是一种有效的抗病毒试剂 (anti-virus agent)。EIDD-1931 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制活性。

Thiabendazole-d4(Synonyms: 2-(4-Thiazolyl)benzimidazole-d4)

Thiabendazole-d4 Chemical Structure

CAS No. : 1190007-20-5

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生物活性

Thiabendazole-d4 is the deuterium labeled EIDD-1931. EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephaliti

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

205.27

Formula

C10H3D4N3S

CAS 号

1190007-20-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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