Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser^[1][2].

Epoxylathyrol has no significant antiproliferative activity in EPG85-257P (parental; IC₅₀>100 uM), EPG85-257RNOV (multidrug resistance [MDR] phenotype; IC₅₀>100 uM), and EPG85-257RDB (multidrug resistance [MDR] phenotype; IC₅₀=70.53 uM)^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

350.45

C₂₀H₃₀O₅

28649-60-7

环氧续随子醇

• Terpenoids
• Diterpenoids

• 植物
• 大戟科
• 大戟

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mariana Alves Reis, et al. Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer. Front Pharmacol. 2020 May 8;11:599.  [Content Brief]

  [2]. Wei Jiao, et al. Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures. Bioorg Med Chem. 2009 Jul 1;17(13):4786-92.  [Content Brief]