上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Guanfu base I (Synonyms: Acorine)
Guanfu base I (Acorine) 是 Guanfu base A 的活性代谢产物，是从 Aconitum coreanum 中分离得到的，具有很强的抗心律失常的作用。
Guanfu base I Chemical Structure
CAS No. : 110225-59-7
| 规格 | 是否有货 | ||
|---|---|---|---|
| 5 mg | 询价 | ||
| 10 mg | 询价 | ||
| 25 mg | 询价 |
* Please select Quantity before adding items.
| 生物活性 |
Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect[1]. |
|---|---|
| 体内研究 (In Vivo) |
The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
387.47 |
| Formula |
C22H29NO5 |
| CAS 号 |
110225-59-7 |
| 结构分类 |
|
| 初始来源 |
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 纯度 & 产品资料 |
Data Sheet (533 KB) 产品使用指南 (1538 KB)
|
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务