标签归档：hgs

Mapatumumab (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)

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Mapatumumab  (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)

Mapatumumab (HGS-ETR1) 是靶向肿瘤坏死因子相关凋亡诱导配体受体 1 (TRAIL-R1) 的全人 IgG1 激动性单克隆抗体。Mapatumumab 可用于肿瘤的研究。

  • Mapatumumab (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)
  • Mapatumumab (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)

  1. Mapatumumab (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)
  2. Mapatumumab (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)

CAS No. : 658052-09-6

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Mapatumumab 相关产品

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生物活性

Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer[1].

同型

Human IgG1 nd
推荐同型对照抗体

Human IgG1 kappa, Isotype Control
种属

Human
体外研究
(In Vitro)

Mapatumumab (0.01-100 μg/mL; 4 h) shows no growth inhibition to Pediatric Preclinical Testing Program (PPTP) cell lines[1].
Mapatumumab (1-100 ng/mL; 24 h) shows significant potentiation of cytotoxicity and synergy when combined with (epirubicin) EPI for bladder cancer cells[2].
Mapatumumab (100 ng/mL; 12 h) induces significant cell apoptosis of T24, 253J and J82 cells with the combination of EPI (1 μg/mL)[2].
Mapatumumab (100 ng/mL; 6-24 h) significantly activates caspase-8, -9 and -3 with the combination of EPI (1 μg/mL)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Mapatumumab 相关抗体:
体内研究
(In Vivo)

Mapatumumab (10 mg/kg; i.p. for three times) controls tumor growth when combined with irradiation[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colo205-xenograft–bearing NMRI (nu/nu) nude mice[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; on days 1, 4, and 8
Result: Showed no significant differences when used alone, but when combined with irradiation (5×3 Gy, d1–5) showed a pronounced tumor regrowth-delay.

Clinical Trial

分子量

151.89 (kDa)

CAS 号

658052-09-6
中文名称

马帕木单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Mapatumumab (Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody)
    Human IgG1 nd
纯度 & 产品资料
Data Sheet (516 KB) 抗体抑制剂使用指南 (1152 KB)

参考文献

  • [1]. Smith MA, et al. Initial testing (stage 1) of mapatumumab (HGS-ETR1) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2010 Feb;54(2):307-10.

    [2]. Ahmed SM, et al. Synergistic induction of apoptosis by mapatumumab and anthracyclines in human bladder cancer cells. Oncol Rep. 2015 Feb;33(2):566-72.  [Content Brief]

    [3]. Marini P, et al. Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions. Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):198-202.  [Content Brief]

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