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Tonlamarsen (Synonyms: ION-904)
Tonlamarsen 是一种血管紧张肽原合成还原剂,具有抗高血压活性。
DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rG-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-T-sp-G-sp-A-sp-T-sp-T-sp-T-sp-G-sp-T-sp-m5C-sp-m5C-sp-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-sp-[2′-O-(2-methoxyethyl)]rG), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]
Tonlamarsen Chemical Structure
CAS No. : 2589926-20-3
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250 mg | 询价 |
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生物活性 |
Tonlamarsen is a angiotensinogen synthesis reducer, with antihypertensive activity[1]. |
IC50 & Target |
Angiotensinogen[1] |
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分子量 |
7021.06 |
Formula |
C241H349N65O12P16S12 |
CAS 号 |
2589926-20-3 |
Sequence |
DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rG-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-T-sp-G-sp-A-sp-T-sp-T-sp-T-sp-G-sp-T-sp-m5C-sp-m5C-sp-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-sp-[2′-O-(2-methoxyethyl)]rG), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate] |
结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
纯度 & 产品资料 |
Data Sheet (524 KB) 产品使用指南 (1538 KB)
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参考文献 |
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