标签归档：lactate

Squalamine lactate (Synonyms: MSI-1256F)

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Squalamine lactate  (Synonyms: MSI-1256F) 纯度: 98.27%

Squalamine lactate 是一种从角鲨体内分到的氨基甾醇，具有抗菌活性，同时可用于新生血管性年龄相关性黄斑变性的研究。

Squalamine lactate (Synonyms: MSI-1256F)

Squalamine lactate Chemical Structure

CAS No. : 320725-47-1

规格 价格 是否有货 数量
1 mg ￥4500 In-stock
5 mg ￥8800 In-stock
10 mg   询价  
50 mg   询价  

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Squalamine lactate 相关产品

•相关化合物库:

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  • Drug Repurposing Compound Library Plus
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生物活性

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

体外研究
(In Vitro)

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Squalamine lactate 相关抗体:
体内研究
(In Vivo)

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

718.04

Formula

C37H71N3O8S
CAS 号

320725-47-1
性状

固体

颜色

Light yellow to yellow

结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 海洋天然产物
  • 其他海洋生物
  • 动物

Squalus acanthias
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 36.66 mg/mL (51.06 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3927 mL 6.9634 mL 13.9268 mL
5 mM 0.2785 mL 1.3927 mL 2.7854 mL
10 mM 0.1393 mL 0.6963 mL 1.3927 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.27%

Data Sheet (598 KB) SDS (252 KB)

COA (264 KB) RP-HPLC (216 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.  [Content Brief]

    [2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.  [Content Brief]

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