Leucinostatin A (Synonyms: Antibiotic P168)

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Leucinostatin A  (Synonyms: Antibiotic P168)

Leucinostatin A (Antibiotic P168) 是一种九肽,对白色念珠菌和新型隐球菌具有显着的活性。 Leucinostatin A 是一种疏水性九肽抗生素。Leucinostatin A 通过减少前列腺基质细胞中胰岛素样生长因子-I 的表达来抑制前列腺癌的生长。具有抗原虫活性。

Leucinostatin A                                          (Synonyms: Antibiotic P168)

Leucinostatin A Chemical Structure

CAS No. : 76600-38-9

规格 价格 是否有货 数量
500 μg ¥3780 3 – 4 周

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生物活性

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].

分子量

1218.61

Formula

C62H111N11O13

CAS 号

76600-38-9

Sequence Shortening

P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}

结构分类
  • Others
初始来源
  • 微生物

Paecilomyces lilacinus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
Data Sheet (526 KB) 产品使用指南 (1538 KB)

参考文献
  • [1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.  [Content Brief]

    [2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.  [Content Brief]

    [3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.  [Content Brief]

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