标签归档：malonyl

Malonyl CoA (Synonyms: Malonyl coenzyme A)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Malonyl CoA  (Synonyms: Malonyl coenzyme A)

Malonyl CoA 是脂肪酸生物合成的底物和脂肪酸氧化抑制剂。Malonyl CoA 也是 线粒体肉碱棕榈酰转移酶1 (CPT) 的可逆抑制剂。

Malonyl CoA (Synonyms: Malonyl coenzyme A)

Malonyl CoA Chemical Structure

CAS No. : 524-14-1

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Malonyl CoA 的其他形式现货产品:

Malonyl CoA lithium

Malonyl CoA 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

丙二酰辅酶A (20 μM，6分钟) 抑制 MCF-7 细胞 CPT1 活性 (降低 75%)[2].
丙二酰辅酶A (0-3 μM) 抑制雌性大鼠肝线粒体中的 CPT1 活性[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Malonyl CoA 相关抗体:
分子量

853.58

Formula

C24H38N7O19P3S
CAS 号

524-14-1
结构分类
  • Others
初始来源
  • 内源性代谢物
  • 人肠道微生物代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (526 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87.  [Content Brief]

    [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23.  [Content Brief]

    [3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.  [Content Brief]

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