标签归档：mesaconitine

Mesaconitine (Synonyms: 中乌头碱；新乌头碱；美沙乌头碱；新乌碱)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Mesaconitine  (Synonyms: 中乌头碱；新乌头碱；美沙乌头碱；新乌碱) 纯度: 98.83%

新乌头碱(Mesaconitine)是乌头属植物的主要活性成分，具有多种药学作用。

Mesaconitine (Synonyms: 中乌头碱；新乌头碱；美沙乌头碱；新乌碱)

Mesaconitine Chemical Structure

CAS No. : 2752-64-9

规格 价格 是否有货 数量
1 mg ￥457 In-stock
5 mg ￥1000 In-stock
10 mg ￥1500 In-stock
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Mesaconitine 相关产品

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生物活性

Mesaconitine is the main active component of genus aconitum plants. IC50 value: Target: in vitro: In HUVECs, 30 microM mesaconitine increased the [Ca(2+)](i) level in the presence of extracellular CaCl(2) and NaCl, and the response was inhibited by KBR7943. Mesaconitine increased intracellular Na(+) concentration level in HUVECs. The [Ca(2+)](i) response by mesaconitine was inhibited by 100 microM D-tubocurarine [1]. Mesaconitine at 30 microM inhibited 3 microM phenylephrine-induced contraction in the endothelium-intact, but not endothelium-denuded, aortic rings [2]. MA promoted the alpha-MT-induced decrease in NE levels in hippocampus, medulla oblongata plus pons and spinal cord [3].

分子量

631.71

Formula

C33H45NO11
CAS 号

2752-64-9
性状

固体

颜色

White to off-white

中文名称

中乌头碱；新乌头碱；美沙乌头碱；新乌碱
结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
初始来源
  • 植物
  • 毛茛科
  • 乌头
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 4.62 mg/mL (7.31 mM; 超声助溶)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5830 mL 7.9150 mL 15.8300 mL
5 mM 0.3166 mL 1.5830 mL 3.1660 mL
10 mM — — —

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.83%

Data Sheet (612 KB) SDS (420 KB)

COA (213 KB) RP-HPLC (209 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Ogura J, et al. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004 Jan 12;483(2-3):139-46.  [Content Brief]

    [2]. Mitamura M, et al. Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium. Eur J Pharmacol. 2002 Feb 2;436(3):217-25.  [Content Brief]

    [3]. Murayama M, et al. Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. Eur J Pharmacol. 1984 May 18;101(1-2):29-36.  [Content Brief]

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