标签归档：msi

Pexiganan (Synonyms: MSI 78 free base)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Pexiganan  (Synonyms: MSI 78 free base) 纯度: 98.66%

Pexiganan (MSI 78 free base) 是 magainin 2 的合成形式类似物。Pexiganan 是一种强效且具有口服活性的广谱抗菌肽。Pexiganan 可用于感染相关的研究，如糖尿病足溃疡感染。

Pexiganan (Synonyms: MSI 78 free base)

Pexiganan Chemical Structure

CAS No. : 147664-63-9

规格 价格 是否有货 数量
5 mg ￥1090 In-stock
10 mg ￥1850 In-stock
50 mg   询价  
100 mg   询价  

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Pexiganan 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

•同靶点产品:

•同靶点蛋白产品:

生物活性

Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].

体外研究
(In Vitro)

Pexiganan (MIC: 0-128 μg/mL approximately) shows broad-spectrum antibacterial activity against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria[2].
Pexiganan (4 μg/mL) inhibits gastric ulcer strain and gastric cancer strain[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Pexiganan 相关抗体:
体内研究
(In Vivo)

Pexiganan (1, 3, 10 or 30 mg/kg, p.o., daily for three consecutive days) shows H. pylori clearance efficiency in H. pylori-infected mouse[3].
Pexiganan (1 mg/kg, i.p.) shows antimicrobial activity in rat models of Gram-negative septic shock[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H. pylori-infected mouse[3].
Dosage: 1, 3, 10 or 30 mg/kg
Administration: Oral administration, daily for three consecutive days.
Result: Lowered H. pylori urease activities in mouse stomachs.
Animal Model: Rat models of Gram-negative septic shock (induced by E.coli ATCC 25922)[4].
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Displayed antimicrobial activities and survival rates of 67.7%.

Clinical Trial

分子量

2477.17

Formula

C122H210N32O22
CAS 号

147664-63-9
性状

固体

颜色

White to off-white

Sequence Shortening

GIGKFLKKAKKFGKAFVKILKK-NH2
结构分类
  • Others
初始来源
  • 动物

the skin of the African clawed frog
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (40.37 mM; 超声助溶)

DMSO 中的溶解度 : 5 mg/mL (2.02 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4037 mL 2.0184 mL 4.0369 mL
5 mM 0.0807 mL 0.4037 mL 0.8074 mL
10 mM 0.0404 mL 0.2018 mL 0.4037 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

扫码获得
动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料

纯度: 99.78%

Data Sheet (604 KB) SDS (252 KB)

COA (257 KB) RP-HPLC (196 KB) MS (71 KB) 元素分析报告 (203 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Lamb HM, et al. Pexiganan acetate. Drugs. 1998 Dec;56(6):1047-52; discussion 1053-4.  [Content Brief]

    [2]. Ge Y, et al. In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother. 1999 Apr;43(4):782-8.  [Content Brief]

    [3]. Zhang XL, et al. The synthetic antimicrobial peptide pexiganan and its nanoparticles (PNPs) exhibit the anti-helicobacter pylori activity in vitro and in vivo. Molecules. 2015 Mar 2;20(3):3972-85.  [Content Brief]

    [4]. Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005 Feb;26(2):207-16.  [Content Brief]

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