Niga-ichigoside F1 (Synonyms: 苦莓苷F1)

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Niga-ichigoside F1  (Synonyms: 苦莓苷F1) 纯度: ≥99.0%

Niga-ichigoside F1 是一种具有口服活性熊果三萜,具有抗高血脂和抗氧化活性。Niga-ichigoside F1 可以预防高脂肪饮食 (HFD) 诱导的肝脂肪变性。

Niga-ichigoside F1                                          (Synonyms: 苦莓苷F1)

Niga-ichigoside F1 Chemical Structure

CAS No. : 95262-48-9

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Niga-ichigoside F1 相关产品

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生物活性

Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].

体外研究
(In Vitro)

Niga-ichigoside F1 (2.5, 5, 10, 20 μM; for 24 hours) inhibits lipid accumu-lation in free fatty acid (FFA)-treated HepG2 cells in a dose-dependent manner. Niga-ichigoside F1 has no effects on cell viability[1].
Both nuclear and cytoplasmic Nrf2 expressions are lowered in Con, Niga-ichigoside F1 (20 μM), FFA (1 mM), and Niga-ichigoside F1 plus FFA treated Nrf2-silenced cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Niga-ichigoside F1 相关抗体:

体内研究
(In Vivo)

Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

666.84

Formula

C36H58O11

CAS 号

95262-48-9

性状

固体

颜色

White to off-white

中文名称

苦莓苷F1

结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 菊科
  • 绢叶旋覆花
  • 植物
  • 唇形科
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (529 KB) SDS (251 KB)

COA (268 KB) HNMR (229 KB) CNMR (193 KB) RP-HPLC (297 KB) MS (883 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Shu-Fang Xia, et al. Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. Food Funct. 2018 Feb 21;9(2):906-916.  [Content Brief]

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