标签归档：norepinephrine

Norepinephrine tartrate (Synonyms: 去甲肾上腺素酒石酸盐; Levarterenol tartrate; L-Noradrenaline tartrate)

发表于由

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Norepinephrine tartrate  (Synonyms: 去甲肾上腺素酒石酸盐; Levarterenol tartrate; L-Noradrenaline tartrate)

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一种有效的肾上腺素能受体 (AR) 激动剂。Norepinephrine tartrate 可以激活 α1、α2、β1 受体。

Norepinephrine tartrate (Synonyms: 去甲肾上腺素酒石酸盐; Levarterenol tartrate; L-Noradrenaline tartrate)

Norepinephrine tartrate Chemical Structure

CAS No. : 51-40-1

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生物活性

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors[1][2][3][4].

IC50 & Target[1]

α1-adrenergic receptor

 

α2-adrenergic receptor

 

Beta-1 adrenergic receptor

 

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2].
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Norepinephrine tartrate 相关抗体:

RT-PCR[2]

Cell Line: Subcutaneous preadipocytes Adipocytes.
Concentration: 10 μM.
Incubation Time: 6 hours.
Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)

Clinical Trial

分子量

319.26

Formula

C12H17NO9
CAS 号

51-40-1
中文名称

去甲肾上腺素酒石酸盐
结构分类
  • Phenols
  • Polyphenols
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36.  [Content Brief]

    [2]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200.  [Content Brief]

    [3]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60.  [Content Brief]

    [4]. Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579.  [Content Brief]

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