标签归档：np

5-Nitro-1,10-phenanthroline (Synonyms: 5-NP)

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5-Nitro-1,10-phenanthroline  (Synonyms: 5-NP) 纯度: 99.88%

5-Nitro-1,10-phenanthroline (5-NP) 是一种 o-Phenanthroline (HY-W004544) 衍生物，是葡萄糖氧化酶 (GOX) 中介，具有抗结核菌活性。5-Nitro-1,10-phenanthroline 可作为氧化酶的氧化还原介质，适用于开发无试剂生物传感器和生物燃料电池。

5-Nitro-1,10-phenanthroline (Synonyms: 5-NP)

5-Nitro-1,10-phenanthroline Chemical Structure

CAS No. : 4199-88-6

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100 mg ￥300 In-stock
500 mg ￥1120 In-stock
1 g ￥1800 In-stock
5 g ￥6120 In-stock
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5-Nitro-1,10-phenanthroline 相关产品

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生物活性

5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1].

体外研究
(In Vitro)

5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages[2].
5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

5-Nitro-1,10-phenanthroline 相关抗体:

Cell Viability Assay[2]

Cell Line: Mtb H37Rv, M. bovis BCG and M. bovis BCG-5NP resistant strain
Concentration: 0-12.5 μM
Incubation Time: 24 hours
Result: Inhibited pathogens with MIC99 values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovis BCG), and >12.5 μM (M. bovis BCG-5NP), respectively.

分子量

225.20

Formula

C12H7N3O2
CAS 号

4199-88-6
性状

固体

颜色

Light yellow to yellow

中文名称

5-硝基-1,10-邻菲啰啉
结构分类
  • Alkaloids
  • Pyridine Alkaloids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料

纯度: 99.88%

Data Sheet (536 KB) SDS (0 KB)

COA (271 KB) HNMR (117 KB) RP-HPLC (192 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Oztekin Y, et al. 1,10-Phenanthroline derivatives as mediators for glucose oxidase. Biosens Bioelectron. 2010 Sep 15;26(1):267-70.  [Content Brief]

    [2]. Kidwai S, et al. Dual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e00969-17.  [Content Brief]

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