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Rachelmycin (Synonyms: CC-1065; NSC 298223)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Rachelmycin  (Synonyms: CC-1065; NSC 298223)

Rachelmycin (CC-1065) 是一种抗肿瘤抗生素和 DNA 烷化剂。Rachelmycin 具有细胞毒性，可作为细胞毒素合成 ADC，并抑制 DNA 合成。Rachelmycin 可用于癌症和感染研究。

Rachelmycin (Synonyms: CC-1065; NSC 298223)

Rachelmycin Chemical Structure

CAS No. : 69866-21-3

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Rachelmycin 相关产品

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生物活性

Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research[1][2][3].

体外研究
(In Vitro)

CC-1065 抑制 DNA 合成，并通过阻断细胞周期在 G2+M 期对细胞周期产生影响。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Rachelmycin 相关抗体:
体内研究
(In Vivo)

Rachelmycin (13.5-250 mg/kg；腹腔注射，每日 1 次，共 3-9 次) 抑制多种小鼠肿瘤模型的肿瘤生长，如：P388，ADJ-PC6，B16，CD8F1，Colon 26 和 L1210 系统。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

703.70

Formula

C37H33N7O8
CAS 号

69866-21-3
中文名称

拉奇霉素
结构分类
  • Antibiotics
  • Disease Research
  • Anticancer
  • Phenols
  • Monophenols
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Streptomyces zelensis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. W C Krueger, et al. Calf Thymus DNA binding/bonding Properties of CC-1065 and Analogs as Related to Their Biological Activities and Toxicities. Chem Biol Interact. 1992 Mar;82(1):31-46.  [Content Brief]

    [2]. Martin DG, et al. CC-1065 (NSC 298223), a potent new antitumor agent improved production and isolation, characterization and antitumor activity. J Antibiot (Tokyo). 1981 Sep;34(9):1119-25.  [Content Brief]

    [3]. Reynolds VL, et al. The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic. J Antibiot (Tokyo). 1986 Mar;39(3):319-34.  [Content Brief]

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