Obtusifolin (Synonyms: 决明蒽醌)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Obtusifolin  (Synonyms: 决明蒽醌) 纯度: 99.80%

Obtusifolin 是从决明子的种子中分离出,通过抑制 NF-kB 通路来调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。Obtusifolin 通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。

Obtusifolin                                          (Synonyms: 决明蒽醌)

Obtusifolin Chemical Structure

CAS No. : 477-85-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2035 In-stock
1 mg ¥650 In-stock
5 mg ¥1850 In-stock
10 mg ¥2868 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Obtusifolin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Antioxidant Compound Library
  • Differentiation Inducing Compound Library
  • Oxygen Sensing Compound Library
  • Medicine Food Homology Compound Library
  • Phenols Library
  • Pyroptosis Compound Library
  • Traditional Chinese Medicine Active Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Anti-Obesity Compound Library
  • Transcription Factor-Targeted Library
  • Anti-Liver Cancer Compound Library
  • Anti-Cancer Natural Product Library
  • Antidepressant Compound Library
  • Anti-inflammatory Traditional Chinese Medicine Active Compound Library
  • Plant-Sourced Natural Product Library
  • Human Metabolite Library
  • Anti-Prostate Cancer Compound Library
  • Osteogenesis Compound Library
  • Cancer Stem Cells Compound Library
  • Pain-Related Compound Library
  • Anti-Hematopathy Compound Library
  • Anti-Ovarian Cancer Compound Library
  • Radioprotector Library

同靶点产品:

同靶点蛋白产品:

生物活性

Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

IC50 & Target[1]

NF-κB

 

体外研究
(In Vitro)

Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Obtusifolin 相关抗体:

分子量

284.26

Formula

C16H12O5

CAS 号

477-85-0

性状

固体

颜色

Yellow to orange

中文名称

决明蒽醌

结构分类
  • Quinones
  • Anthraquinones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 豆科
  • 决明子
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (35.18 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

扫码获得
动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.80%

Data Sheet (606 KB) SDS (392 KB)

COA (268 KB) HNMR (149 KB) CNMR (160 KB) RP-HPLC (266 KB) MS (178 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928.  [Content Brief]

    [2]. Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40.  [Content Brief]

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务