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Mirtazapine D3(Synonyms: 米氮平 D3; Org3770 D3; 6-Azamianserin D3)

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Mirtazapine D3 (Synonyms: 米氮平 D3; Org3770 D3; 6-Azamianserin D3) 纯度: 99.49%

Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) 是 Mirtazapine 的氘代物。Mirtazapine 是 5-HT receptor 受体抑制剂。 Mirtazapine 是一种有效的具有口服活性去甲肾上腺素能和特异性 5-羟色胺抗抑郁试剂 (NaSSA)，可阻断 5-HT2 和 5-HT3 受体。

Mirtazapine D3(Synonyms: 米氮平 D3; Org3770 D3; 6-Azamianserin D3)

Mirtazapine D3 Chemical Structure

CAS No. : 1216678-68-0

规格 价格 是否有货 数量
1 mg ￥1200 In-stock
5 mg ￥4500 In-stock
10 mg ￥7700 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

IC50 & Target

5-HT2 Receptor

 

5-HT3 Receptor

 

体内研究
(In Vivo)

Mirtazapine (intraperitoneal injection; 10–50 mg/Kg; 14 days) treatment normalizes heart rate, breath rate, anxiety levels and eliminates the hopping behavior observed in MeCP2-null mice, leading to improved phenotypic score[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MeCP2 null mice[2]
Dosage: 10-50 mg/Kg
Administration: Intraperitoneal injection; 10-50 mg/Kg; 14 days
Result: Restored the thickness of MeCP2-null mice somatosensory cortex, especially of layers II-III and VI.

分子量

268.37

Formula

C17H16D3N3
CAS 号

1216678-68-0
中文名称

米氮平 D3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64.

    [2]. Kooyman AR, et al. Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells.Neuropharmacology. 1994 Mar-Apr;33(3-4):501-7.

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