Synephrine hydrochloride (Synonyms: 辛弗林盐酸盐; Oxedrine hydrochloride)

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Synephrine hydrochloride  (Synonyms: 辛弗林盐酸盐; Oxedrine hydrochloride) 纯度: 99.66%

Synephrine (Oxedrine) hydrochloride,一种生物碱,是一种来自 Citrus aurantiumα-adrenergicβ-adrenergic 激动剂。Synephrine hydrochloride 是一种拟交感神经化合物,可用于减肥。

Synephrine hydrochloride                                          (Synonyms: 辛弗林盐酸盐; Oxedrine hydrochloride)

Synephrine hydrochloride Chemical Structure

CAS No. : 5985-28-4

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生物活性

Synephrine (Oxedrine) hydrochloride, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss[1][2].

IC50 & Target

β adrenergic receptor

 

体内研究
(In Vivo)

Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2]
Dosage: 1 mg/kg per 12 hours
Administration: Oral gavage; for 8 days
Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.

分子量

203.67

Formula

C9H14ClNO2

CAS 号

5985-28-4

性状

固体

颜色

White to off-white

中文名称

辛弗林盐酸盐

结构分类
  • Alkaloids
  • Other Alkaloids
  • Phenols
  • Monophenols
初始来源
  • 植物
  • 芸香科
  • 酸橙
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 100 mg/mL (490.99 mM)

DMSO 中的溶解度 : ≥ 52 mg/mL (255.31 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.9099 mL 24.5495 mL 49.0990 mL
5 mM 0.9820 mL 4.9099 mL 9.8198 mL
10 mM 0.4910 mL 2.4550 mL 4.9099 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

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This equation is commonly abbreviated as: C1V1 = C2V2

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工作液所需浓度 : mg/mL

该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料

纯度: 99.66%

Data Sheet (598 KB) SDS (393 KB)

COA (169 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90.  [Content Brief]

    [2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8.  [Content Brief]

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