标签归档：phenylbutyrate

Glycerol phenylbutyrate-d5(Synonyms: HPN-100-d5)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Glycerol phenylbutyrate-d5 (Synonyms: HPN-100-d5)

Glycerol phenylbutyrate-D5 是Glycerol phenylbutyrate 的氘代标记物。Glycerol phenylbutyrate 是 sigma-2 (σ2) 受体的一个配体，其 pKi 值为 8.02。Glycerol phenylbutyrate (GPB) 也是氨清除剂。

Glycerol phenylbutyrate-d5(Synonyms: HPN-100-d5)

Glycerol phenylbutyrate-d5 Chemical Structure

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生物活性

Glycerol phenylbutyrate-D5 is a deuterium labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug[1][2].

IC50 & Target

σ2 receptor[1].
体内研究
(In Vivo)

Glycerol phenylbutyrate (GPB) has the potential for the treatment of hyperammonemia. Glycerol phenylbutyrate (GPB) may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders[1][2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

535.68

Formula

C33H33D5O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (476 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Rescifina A, et al. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. Eur J Pharm Sci. 2017 Aug 30;106:94-101.

    [2]. Oishi K, et al. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev Endocrinol Metab. 2014 Sep;9(5):427-434.

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