Sulfadoxine-d4 (Sulphadoxine-d4) is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

314.35

C₁₂H₁₀D₄N₄O₄S

1330266-05-1

磺胺多辛 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html

  [3]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine

  [4]. D’Alessandro S, et al. The Use of Antimalarial Drugs against Viral Infection. Microorganisms. 2020 Jan 8;8(1). pii: E85.