标签归档：sulfate

Catharanthine Sulfate (Synonyms: 硫酸长春质碱; (+)-3,4-Didehydrocoronaridine Sulfate)

发表于由

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Catharanthine Sulfate  (Synonyms: 硫酸长春质碱; (+)-3,4-Didehydrocoronaridine Sulfate)

Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate 是抗癌长春花生物碱的一种成分，可抑制电压驱动的 L 型 Ca2+ 通道 (VOCC)。Catharanthine Sulfate 对心肌细胞和血管平滑肌细胞 (VSMC) 中 VOCC 电流的 IC50 分别为 220 μM 和 8 μM。Catharanthine Sulfate 可降低血压 (BP)、心率 (HR)。Catharanthine Sulfate 具有抗癌活性。

Catharanthine Sulfate (Synonyms: 硫酸长春质碱; (+)-3,4-Didehydrocoronaridine Sulfate)

Catharanthine Sulfate Chemical Structure

CAS No. : 153230-94-5

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生物活性

Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity[1][2].

IC50 & Target

L-type calcium channel

 

体内研究
(In Vivo)

Catharanthine ((+)-3,4-Didehydrocoronaridine；0.5-20 mg/kg；静脉给药；单剂量) Sulfate 可引起血压和心率的剂量依赖性降低[1]。
Catharanthine (40 mg/kg；腹腔注射；单剂量) Sulfate 急性给药在 1 小时和 24 小时在雄性和雌性小鼠中诱导类似的抗抑郁样活性[2]。
Catharanthine (20 mg/kg；腹腔注射；连续 14 天) Sulfate 在 D7 或 D14 增加小鼠游泳时间并减少不动时间[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 13-week-old male SpragueDawley rats (300-350 g)[1]
Dosage: 0.5-20 mg/kg
Administration: IV; single dose
Result: Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.

分子量

434.51

Formula

C21H26N2O6S
CAS 号

153230-94-5
中文名称

硫酸长春质碱
结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 植物
  • 夹竹桃科
  • 长春花
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (538 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92.  [Content Brief]

    [2]. Hugo R Arias, et al. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454.  [Content Brief]

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