标签归档：tectol

Tectol

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Tectol  纯度: 98.32%

Tectol，从 Lippia sidoides 中分离，对人白血病细胞株 HL60 和 CEM 具有显著的抑制作用。Tectol 是一种 farnesyltransferase (FTase) 抑制剂，在人和布氏锥虫的 IC50 分别为 2.09 和 1.73 μM。Tectol 抑制耐药恶性疟原虫 (FcB1)， IC50 为 3.44 μM。

Tectol

Tectol Chemical Structure

CAS No. : 24449-39-6

规格 价格 是否有货 数量
1 mg ￥1300 In-stock
5 mg ￥2700 In-stock
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Tectol 相关产品

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生物活性

Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

IC50 & Target

Plasmodium

 

分子量

450.53

Formula

C30H26O4
CAS 号

24449-39-6
性状

固体

颜色

White to off-white

结构分类
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 98.32%

Data Sheet (534 KB) SDS (393 KB)

COA (274 KB) HNMR (80 KB) RP-HPLC (241 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795.  [Content Brief]

    [2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.  [Content Brief]

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