标签归档：thromboxane

Thromboxane A2 (Synonyms: 血栓素A2; TXA2)

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Thromboxane A2  (Synonyms: 血栓素A2; TXA2)

Thromboxane A2 (TXA2) 是花生四烯酸 (HY-109590) 通过环氧合酶途径代谢产生的一种前列腺素类介质。Thromboxane A2 激活血栓素-前列腺素 (TP) 受体。Thromboxane A2 是一种有效的血管收缩剂类花生酸。Thromboxane A2 通过刺激平滑肌细胞导致有效的血管收缩。Thromboxane A2 作为强直免疫调节剂来调节适应性免疫反应。

Thromboxane A2 (Synonyms: 血栓素A2; TXA2)

Thromboxane A2 Chemical Structure

CAS No. : 57576-52-0

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Thromboxane A2 相关产品

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生物活性

Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses[1][2][3].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

TP

 

体外研究
(In Vitro)

Thromboxane A2 (300 nM, 12 h) 可调节内皮细胞迁移、血管生成和肿瘤转移[3]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Thromboxane A2 相关抗体:
Clinical Trial

分子量

352.47

Formula

C20H32O5
CAS 号

57576-52-0
中文名称

血栓素A2
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Matthew A Sparks, et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 2013 Jan;61(1):166-73.  [Content Brief]

    [2]. Federica Moalli, et al. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med. 2014 Dec 15;211(13):2507-17.  [Content Brief]

    [3]. Nie D, et al. Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem Biophys Res Commun. 2000 Jan 7;267(1):245-51.  [Content Brief]

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