标签归档：tolcapone

Tolcapone D7(Synonyms: Ro 40-7592 D7)

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Tolcapone D7 (Synonyms: Ro 40-7592 D7)

Tolcapone D7 (Ro 40-7592 D7) 是 Tolcapone 的氘代物。Tolcapone 是一种选择性，有效和口服的 COMT 抑制剂。Tolcapone 还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可防止 PC12 细胞中这两种蛋白质聚集引起的细胞外毒性。

Tolcapone D7(Synonyms: Ro 40-7592 D7)

Tolcapone D7 Chemical Structure

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生物活性

Tolcapone D7 (Ro 40-7592 D7) is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

IC50 & Target

COMT[1]
α-syn and Aβ42 oligomerization, fibrillogenesis[2]
分子量

280.28

Formula

C14H4D7NO5
中文名称

托卡朋 D7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Paterson NE, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res. 2011 Jan;69(1):41-50.

    [2]. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54.

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